One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine (Plaquenil), a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus. What is the dosage of plaquenil Lorazepam and hydroxychloroquine Plaquenil westport ct visual field Can you take phentermine with plaquenil Drug-Induced Hyperpigmentation caused by Plaquenil Hydroxychloroquine Plaquenil Hydroxycholoroquine Side Effects. Dermatologic side effects have included mucocutaneous hyperpigmentation, nonlight-sensitive psoriasis, bleaching of hair, alopecia, pruritus, photosensitivity, and skin eruptions such as urticarial, morbilliform, lichenoid, maculopapular, purpuric, erythema annulare centrifugum, Stevens-Johnson syndrome, acute generalized exanthematous pustulosis, and exfoliative dermatitis. Hydroxychloroquine HCQ-associated hyperpigmentation is uncommon, with onset ranging from 3 months to 22 years following the initiation of therapy1. A 32-year-old woman presented with a 1.5-year history of symmetric polyarthritis, positive rheumatoid factor, and anticyclic citrullinated peptide antibody, without erosive joint changes. This skin hyperpigmentation was identified as an hydroxychloroquine adverse effect based on ongoing exposure and the drug was suspended; unfortunately it was not possible to see an improvement due to early death of the patient. It is imperative that patients and physicians are aware of and watch for this drug’s ocular side effects. Retinal toxicity from hydroxychloroquine is rare, but even if the medication is discontinued, vision loss may be irreversible and may continue to progress. Plaquenil induced hyperpigmentation Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses, Hydroxychloroquine-induced Hyperpigmentation of the Skin. Chloroquine resistance treatmentHydroxychloroquine copay assistancePlaquenil cost per pillDoes plaquenilHydroxychloroquine brands Drug-induced hyperpigmentation is a relatively frequent reason for consultation, especially in polypharmacy patients. The sample may have been biased as many patients receiving treatments frequently associated with drug-induced hyperpigmentation, such as antineoplastic drugs, are diagnosed and treated by other specialties, such as oncologists. Drug-Induced Hyperpigmentation Review and Case Series American Board.. Woman in grey hydroxychloroquine-induced hyperpigmentation. PDF Hydroxychloroquine-induced hyperpigmentation a case report.. Pigmentation has been associated with drug therapy or adrenal insufficiency; however, in many cases the cause cannot be identified 15. The greatest significance of chloroquine-induced hyper-pigmentation is the possibility that it may be a marker for a more serious side effect. Irreversible retinopathy HCQ is often prescribed for longer durations and may be associated with cutaneous adverse effects such as yellow-brown or slate-grey pigmentation, bleaching of hair, exacerbation of pre-existing psoriasis, cutaneous rashes and pruritus.1 Cutaneous pigmentation occurs in 10%–30% patients, most commonly over shins, face and palate after approximately 4 months of receiving HCQ.2 The histopathology of HCQ-induced pigmentation consists of yellow-brown granules within macrophages and in the. The few reports of bluish pigmentation with HCQ described resolution within a few months or did not specifiy the duration of pigmentation after discontinuation of the drug 4, 5, 6. Hydroxychloroquine is converted to an inactive metabolite in the liver and excreted in urine 25% in the active form and bile.