How does chloroquine kill the malaria parasite

Discussion in 'Aralen' started by substatic, 06-Mar-2020.

  1. nif User

    How does chloroquine kill the malaria parasite


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    In addition, chloroquine interferes with FP sequestration and causes toxic nonhemozoin FP to accumulate to lethal levels in erythrocytes parasitized with malaria parasites. Evidently, this is how chloroquine kills malaria parasites. It is desirable, therefore, to know more about FP sequestration and how it is affected by chloroquine. Malaria parasites possess a catalyst for FP sequestration which is modulated by treatment with quinoline antimalarial drugs such as chloroquine and quinine. Plasmodium species have to digest hemoglobin inside the red blood cell to survive - but the heme molecule can be toxic when released. Therefore, the parasite tries to sequester that away. Chloroquine interferes with that step - thus leading to a slow poisoning of the parasite. Hope that helps. However, the efficiency of chloroquine has been severely impacted by the recent development of chloroquine resistant plasmodium falciparum parasites. The development of chloroquine resistance by malaria parasites is increasing at an alarming rate especially in the tropical countries where it is used extensively as an antimalarial drug 2.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    How does chloroquine kill the malaria parasite

    Chloroquine Oral Uses, Side Effects, Interactions., Can you tell me how chloroquine kill the malaria parasite.

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  6. How does chloroquine kill the malaria parasite? How does chloroquine work? Does it help cerebral malaria? For my biology coursework, I need to talk about effective treatments for malaria, so I decided to chose chloroquine as one of them. However, I can't seem to find any good websites with relevant information, or any websites with data.

    • How does chloroquine kill the malaria parasite? How does..
    • Chloroquine Resistance in Plasmodium falciparum - microbewiki.
    • Avloclor chloroquine - Netdoctor.

    Chloroquine is still the drug of choice for sensitive malaria parasites although ACTs are used increasingly. Chloroquine is therefore used widely for P. vivax, P. malariae and P. ovale, but except in a very few areas has been replaced for P. falciparum treatment. The time-honoured oral chloroquine regimen of 25 mg base/kg spread over 3 days 10, 10, 5 or 10, 5, 5, 5 mg/kg at 24-hour intervals can be condensed into 36 hours of drug administration. Chloroquine-resistant P. falciparum first developed independently in three to four areas in Southeast Asia, Oceania, and South America in the late 1950s and early 1960s. Since then, chloroquine resistance has spread to nearly all areas of the world where falciparum malaria is transmitted. Malaria is the world's deadliest parasitic disease. It kills more than 300,000 people per year, according to the World Health Organization, and affects up to 300 million. One of the biggest.

     
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    Chloroquine Uses, Side Effects & Warnings -