Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking chloroquine: Incidence not known Some side effects of chloroquine may occur that usually do not need medical attention. Can hydroxychloroquine cause insomnia Plaquenil uses Chloroquine sulphate DIAGNOSIS. Hydroxychloroquine myopathy. DISCUSSION. Hydroxychloroquine HCQ, a commonly used drug for various autoimmune conditions, is widely distributed into cardiac and skeletal muscle tissue. It is a large amphiphilic molecule that can cause both myofiber necrosis and vacuolar myopathy. Hydroxychloroquine-Induced Myopathy. Article. role. 3, 4 Hydroxychloroquine-induced neuromyopathy has been less frequent and less aggressive 5 than that secondary to chloroquine. That is why. Chloroquine is an antimalarial agent also used as standard treatment for a variety of rheumatologic and dermatologic disorders.1,2 Myopathy and, to a lesser extent, neuropathy are well-documented complications of therapy with chloroquine and other antimalarial agents.1,3 Chloroquine typically produces a vacuolar myopathy1,2 characterized by progressive proximal weakness that resolves rapidly. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Chloroquine myopathy Hydroxychloroquine-Induced Toxic Myopathy Causing Respiratory Failure, Hydroxychloroquine-Induced Myopathy Request PDF How long can i stay on plaquenilHydroxychloroquine retinopathy screening guidelinesHydroxychloroquine plaquenil for malaria protection Chloroquine is an antimalarial agent also used as standard treatment for a variety of rheumatologic and dermatologic disorders. 1,2 Myopathy and, to a lesser extent, neuropathy are well-documented complications of therapy with chloroquine and other antimalarial agents. 1,3 Chloroquine typically produces a vacuolar myopathy 1,2 characterized by progressive proximal weakness that resolves rapidly with discontinuation of the drug. 4 Vacuoles may or may not be rimmed and contain heterogeneous. Chloroquine myopathy and neuropathy with elevated CSF.. Chloroquine myopathy and neuropathy with elevated CSF protein.. Chloroquine myopathy. Chloroquine-induced myopathy. C Posada, A García-Cruz, I García-Doval, B San Millán, and S Teijeira. Lupus 2011 20 7, 773-774 Download Citation. Chloroquine myopathy 240102007. Vacuolar myopathy associated with chloroquine, lupus erythematosus and thymoma. Report of a case with unusual mitochondrial changes and lipid accumulation in muscle. Mastaglia FL, Papadimitriou JM, Dawkins RL, Beveridge B J Neurol Sci 1977 Dec;343315-28. Although the precise incidence is unknown, drug-induced myopathy is among the most common causes of muscle disease. Drug-induced myopathy ranges from mild myalgias with or without mild weakness to chronic myopathy with severe weakness and to massive rhabdomyolysis with acute renal failure.