I would appreciate feedback on the reasoning outlined below. I have convinced myself that it makes sense, but am looking for independent feedback and have been struggling to get it. Ocular side effects hydroxychloroquine Oregano oil and plaquenil Chloroquine/hydroxychloroquine is extruded to the extracellular medium mostly by exocytosis and/or through the action of the multidrug resistance protein MRP-1, a cell surface drug transporter belonging to the ATP-binding cassette family, which also includes the more thoroughly studied P-glycoprotein. Mechanism of action of hydroxychloroquine as an antirheumatic drug. Fox RI1. Author information 1Department of Rheumatology, Scripps Clinic and Research Foundation, La Jolla, CA 92037. The antimalarial agents chloroquine and hydroxychloroquine have been used widely for the treatment of rheumatoid arthritis and systemic lupus erythematosus. A wide variety of mechanisms of antirheumatic action have been proposed for chloroquine and hydroxychloroquine, but any model must account for a the slow onset of action usually 8 to 12 weeks, in contrast to the rapid onset of therapeutic benefit after administration of salicylates, corticosteroids, or nonsteroidal anti-inflammatory drugs; b. , etc.), or provide argument why this is a dumb idea. I would greatly appreciate it if someone could knit-pick this with a fine tooth comb and try and find some mistake I've made (off by a order of magnitude? Mechanism of action hydroxychloroquine Hydroxychloroquine - DrugBank, Mechanism of action of hydroxychloroquine as an. Plaquenil drug assistance programIs mefloquine in plaquenilPlaquenil off label usesPlaquenil effects on fetusWhat else can i take if i cant take plaquenil Cytochrome P450 enzymes converts hydroxychloroquine into its active metabolite, desethyl hydroxychloroquine.6 The onset of action may take up to 4–6 weeks post-commencement of therapy, and it may take 3–6 months to achieve maximal clinical efﬁcacy. The recommended maintenance dose of hydroxychloroquine is 200–400 mg daily. REVIEW Hydroxychloroquine in lupus emerging evidence.. Antimalarial Drugs SpringerLink. Plaquenil hydroxychloroquine sulfate dose, indications.. Jun 28, 2013 · Mechanism of action The precise mechanism by which hydroxychloroquine exhibits activity against Plasmodium is not known. Hydroxychloroquine, like chloroquine, is a weak base and may exert its effect by concentrating in the acid vesicles Mechanism of action of antimalarial drugs inhibition of antigen processing and presentation. Lupus 1993; 2 Suppl 1S9. Fox R. Anti-malarial drugs possible mechanisms of action in autoimmune disease and prospects for drug development. Hydroxychloroquine HCQ is nearly identical in structure to CQ and has a similar mechanism of action and therapeutic efficacy in rheumatological and infectious diseases. Like CQ, it also has a long half-life, and a very high volume of distribution.