Curvilinear bodies hydroxychloroquine cardiomyopathy

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  1. sharada Well-Known Member

    Curvilinear bodies hydroxychloroquine cardiomyopathy


    However, the exact mechanism of HCQ cardiotoxicity remains unclear and it is difficult to identify risk factors. We present a case of twin sisters who both suffered from systemic lupus erythematosus (SLE) and HCQ-induced cardiomyopathy presenting with decompensated heart failure (HF), suggesting that genetic predisposition might be a factor in HCQ-induced cardiomyopathy.

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    Dilated Cardiomyopathy and Hydroxychloroquine-induced Phospholipidosis From Curvilinear Bodies to Clinical Suspicion. Article in English, Spanish Di Girolamo F1, Claver E2, Olivé M3, Salazar-Mendiguchía J1, Manito N1, Cequier Á1. HCQ neuromyotoxicity is a rare complication characterized by proximal muscle weakness, normal creatinine kinase levels, and characteristic ultrastructural changes on muscle biopsy of curvilinear body formation. Hydroxychloroquine cardiotoxicity presenting as a rapidly evolving biventricular cardiomyopathy key diagnostic features and literature review. Curvilinear bodies in particular appear to be the most specific histological indicator of antimalarial-related cardiotoxicity and these structures are not seen in differential diagnoses of some of.

    Retinal toxicity, neuromyopathy, and cardiac toxicity are recognized toxicities following prolonged use (1). Hydroxychloroquine (HCQ) is one of the antimalarial drugs that have been used for decades to treat rheumatic diseases (1).

    Curvilinear bodies hydroxychloroquine cardiomyopathy

    New clinical and ultrastructural findings in., Hydroxychloroquine-induced toxic myopathy causing respiratory.

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  3. Oct 30, 2019 Daily hydroxychloroquine base doses 5 mg/kg actual body weight were associated with an ~10% risk of retinal toxicity within 10 years of treatment and an almost 40% risk after 20 years of therapy. Risk is most accurately assessed on the basis of duration of use relative to daily dose/body weight Marmor AAO 2016; Melles 2014.

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    Electron microscopy of the myocytes demonstrated dense, myeloid, and curvilinear bodies. The diagnosis of hydroxychloroquine-induced cardiomyopathy was made based on the clinical, hemodynamic, and pathologic findings. Hydroxychloroquine-induced cardiomyopathy and heart failure in twins. Introduction. Hydroxychloroquine HCQ is one of the antimalarial drugs that have been used for decades to treat rheumatic diseases. Retinal toxicity, neuromyopathy, and cardiac toxicity are recognized toxicities following prolonged use. HCQ-induced cardiomyopathy is one of the rare but severe complications which could. Hydroxychloroquine HCQ, a common anti-rheumatic medication, can be cardiotoxic and cause systolic or diastolic heart failure HF. A 65 year old man presented with acute decompensated HF. He had a history of rheumatoid arthritis, and had been treated with hydroxychloroquine for the last 8 years.

     
  4. Alsker Moderator

    Plaquenil (hydroxychloroquine) belongs to a group of medicines called quinolines. Plaquenil Uses, Dosage & Side Effects - Albuterol Side Effects Common, Severe, Long Term - Side Effects of Protonix Pantoprazole, Warnings, Uses
     
  5. mihey1978 New Member

    Hydroxychloroquine - an overview ScienceDirect Topics Hydroxychloroquine has been recommended as a steroid-sparing agent and as a drug that is effective in treating the dermatitis of JDM. 609 Olson and Lindsley 610 reported significant improvement of the rash following 3 months and of muscle weakness after 6 months of treatment in a dose of 2 to 5 mg/kg/day in nine children. Anecdotal experience.

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